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In a groundbreaking development that could transform global vaccination efforts, the UK has launched the world's first clinical trial for a fridge-free vaccine. The Stablepharma tetanus-diphtheria vaccine (SPVX02), developed by UK-based biotech company Stablepharma, boasts complete stability at room temperature, eliminating the need for the complex and costly "cold chain" required by traditional vaccines. This innovation holds the potential to significantly increase access to life-saving jabs, particularly in remote and resource-limited regions, Daily Dazzling Dawn understand.
The first-in-human trial is underway at the National Institute for Health and Care Research (NIHR) Southampton clinical research facility at University Hospital Southampton. The trial's success could pave the way for fridge-free versions of up to 60 other vaccines, according to Stablepharma.
One of the most significant obstacles to global vaccine distribution is the necessity of maintaining a constant cold chain, from the point of manufacture to administration. The World Health Organisation (WHO) estimates that up to half of all vaccines are wasted globally each year due to temperature control failures and the logistical challenges of maintaining an unbroken cold chain. Stablepharma's technology offers a solution to this critical problem by converting existing approved vaccines into fridge-free versions capable of long-term storage at room temperature.
Health and Social Care Secretary, Wes Streeting, hailed the trial as a potential "game changer and lifesaver globally," emphasizing the UK's leading role in vaccine innovation. He stated, "This could unlock new ways for poorer nations to deliver vaccines to their patients, where they’re often needed the most."
Professor Saul Faust from the University of Southampton, leading the clinical trial alongside Stablepharma chief development officer Dr Karen O’Hanlon, expressed his excitement at seeing "cutting-edge UK science reach the milestone of a first clinical trial." He added that the research will be "an important step toward exploring whether this innovation could eradicate vaccine wastage and move away from the need for the cold-chain."
The trial is expected to conclude this summer, with results anticipated by the end of the year. Stablepharma aims to have the new vaccine in global use by 2027. This UK-led initiative represents a major step forward in ensuring equitable access to vaccines worldwide, potentially saving countless lives and strengthening global health security.
